脑机接口综合康复训练对亚急性期脑卒中疗效的静息态功能磁共振研究

doi:10.3969/j.issn.1006-9771.2020.01.014

Abstract

Abstract:

Objective To investigate the topological alterations in brain functional networks following comprehensive treatment including brain-computer interface (BCI) training in subacute stroke subjects.
Methods From January, 2018 to June, 2019, 14 subacute stroke patients with moderate to severe upper limbs paralysis accepted routine physical therapy, occupational therapy and BCI training based on motor imagery, for four weeks. They were assessed with Fugl-Meyer Assessment-Upper Extremities (FMA-UE), Action Research Arm Test (ARAT) and Wolf Motor Function Test (WMFT) before and after treatment, while the functional connectivity (FC) was investigated with resting state functional magnetic resonance imaging.
Results The scores of FMA-UE, ARAT and WMFT increased after treatment (|t| > 5.298, Z = -3.297, P < 0.01). The FC also increased across the whole brain, including temporal, parietal, occipital lobes and subcortical regions. The FC between left piriform cortex of parietal lobule (BA5L) and right medial surface of temporal lobe (BA48R), as well as those between left precentral gyrus (BA4L) and right anterior transverse temporal gyrus (BA41R) ( r > 0.416, P < 0.05).
Conclusion Comprehensive rehabilitation including BCI training may promote recovery of motor function and activities of FC in brain in subacute stroke patients.

Key words: stroke, brain-computer interface, motor imagery, resting state functional magnetic resonance imaging, neural plasticity, functional connectivity

CLC Number:

R743.3

WU Qiong,REN Shi-yuan,YUE Zan,GE Yun-xiang,MA Di,ZHAO Hong-liang,LIU Gang,WANG Jing,PAN Yu,DOU Wei-bei. Brain-computer Interface and Comprehensive Training for Stroke: A Resting State Functional Magnetic Resonance Imaging Study[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(1): 77-84.

Figures/Tables 6

References 37

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项目		统计量
性别(n)	男	9
性别(n)	女	5
年龄(岁)		54.501±3.550
卒中类型(n)	脑梗死	12
卒中类型(n)	脑出血	2
偏瘫侧(n)	左	8
偏瘫侧(n)	右	6
病程(月)		1.500±0.711

时间	FMA-UE	ARAT	WMFT
训练前	20.14±13.21	9.50(3.00,23.25)	30.07±12.66
训练后	35.36±15.92	24.00(10.00,45.25)	47.79±18.68
训练前后差值	14.71±7.80	8.50(3.75,24.00)	18.14±12.03
t/Z值^a	-6.612	-3.297	-5.298
P值^a	< 0.001	0.001	< 0.001

种子点	连接点	训练前	训练后	t值	P值
BA4L	BA41R	-0.008±0.212	0.135±0.227	2.317	0.038
BA6R	BA7L	-0.177±0.252	0.049±0.214	3.723	0.007
BA6R	BA2R	0.489±0.133	0.590±0.141	2.542	0.025
BA6R	BA3R	0.586±0.232	0.697±0.085	2.321	0.037
BA6R	BA37L	-0.214±0.183	-0.057±0.213	3.092	0.009
BA6R	BA7R	0.045±0.228	0.198±0.270	2.774	0.016
BA6R	BA19L	-0.207±0.227	-0.0132±0.287	2.181	0.048
BA5L	BA48R	-0.128±0.174	-0.006±0.224	2.204	0.046
BA5L	BA48L	-0.022±0.224	0.088±0.196	2.185	0.048
BA5R	BA44L	-0.309±0.1312	-0.200±0.152	2.682	0.019
BA8R	BA7R	0.187±0.292	0.051±0.276	2.251	0.042
BA8R	BA18R	-0.337±0.140	-0.146±0.175	3.371	0.005
BA8R	BA18L	-0.340±0.128	-0.192±0.161	3.978	0.002
BA8R	BA19R	-0.382±0.142	-0.208±0.191	4.764	0.000

FC	临床评分	r值	P值
BA4L-BA41R	FMA-UE	0.485	0.009
	ARAT	0.416	0.028
	WMFT	0.505	0.006
BA5L-BA48R	FMA-UE	0.522	0.004
	ARAT	0.544	0.003
	WMFT	0.696	< 0.001

Brain-computer Interface and Comprehensive Training for Stroke: A Resting State Functional Magnetic Resonance Imaging Study

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