microRNA-137基因多态性与缺血性卒中后抑郁的相关性

doi:10.3969/j.issn.1006-9771.2020.05.019

Abstract

Abstract:

Objective To analyze the relationship between microRNA-137 gene polymorphisms and ischemic post-stroke depression (PSD).Methods January, 2017 to January, 2019, the single nucleotide polymorphism (SNP) of rs1625579 in microRNA-137 was genotyped in 250 ischemic PSD patients and 250 healthy controls with SNaPshot. The expression of microRNA-137 was measured with quantitative real-time polymerase chain reaction in the mononuclear cells, and the association of the SNP rs1625579 with microRNA-137 expression was analyzed.Results The allele T was more in the patients than in the controls (OR = 2.033, 95%CI 1.255 to 3.294, P= 0.003), as well as the genotype TT (OR = 2.139, 95%CI 1.272~3.595, P= 0.004). The microRNA-137 expression was less in the patients than in the controls (t = 28.23, P< 0.001). For the controls, the microRNA-137 expression was also less in those with genotype of TT than with GT and GG (t = 3.764, P< 0.001).Conclusion The genotype TT of SNP rs1625579 in microRNA-137 is a risk factor of susceptibility to ischemic PSD, which may associate with the decrease of expression of microRNA-137.

Key words: ischemic stroke, post-stroke depression, microRNA-137, rs1625579, gene polymorphisms

CLC Number:

R743.3

FU Jia-wu,WU Hao,LI Jun-liang,YE Ye,CHEN Jing,ZHOU Hai-hong,LI You. Association between microRNA-137 Gene Polymorphisms and Ischemic Post-stroke Depression[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(5): 588-591.

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[1]	GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015[J]. Lancet, 2016, 388(10053):1459-1544. doi: 10.1016/S0140-6736(16)31012-1
[2]	Chugh C. Acute ischemic stroke: management approach[J]. Indian J Crit Care Med, 2019, 23(Suppl 2):S140-S146.
[3]	Xiong Y, Manwani B, Fisher M. Management of acute ischemic stroke[J]. Am J Med, 2019, 132(3):286-291. doi: 10.1016/j.amjmed.2018.10.019
[4]	Robinson R G, Jorge R E. Post-stroke depression: a review[J]. Am J Psychiatry, 2016, 173(3):221-231. doi: 10.1176/appi.ajp.2015.15030363 pmid: 26684921
[5]	Cai W, Mueller C, Li Y J, et al. Post stroke depression and risk of stroke recurrence and mortality: a systematic review and meta-analysis[J]. Ageing Res Rev, 2019, 50:102-109. doi: S1568-1637(18)30315-5 pmid: 30711712
[6]	Paolucci S, Iosa M, Coiro P, et al. Post-stroke depression increases disability more than 15% in ischemic stroke survivors: a case-control study[J]. Front Neurol, 2019, 10:926. doi: 10.3389/fneur.2019.00926 pmid: 31507525
[7]	Miranda J J, Moscoso M G, Toyama M, et al. Role of mHealth in overcoming the occurrence of post-stroke depression[J]. Acta Neurol Scand, 2018, 137(1):12-19. doi: 10.1111/ane.12832 pmid: 28901543
[8]	Lu T X, Rothenberg M E. MicroRNA[J]. J Allergy Clin Immunol, 2018, 141(4):1202-1207. doi: 10.1016/j.jaci.2017.08.034
[9]	Biggar K K, Storey K B. Functional impact of microRNA regulation in models of extreme stress adaptation[J]. J Mol Cell Biol, 2018, 10(2):93-101. doi: 10.1093/jmcb/mjx053 pmid: 29206937
[10]	Jolana L, Kamil D. The role of microRNA in ischemic and hemorrhagic stroke[J]. Curr Drug Deliv, 2017, 14(6):816-831.
[11]	鲁豫, 田小军, 史莉瑾, 等. MiR-137在缺血性卒中后抑郁患者外周血中的表达及其临床意义[J]. 临床神经病学杂志, 2017, 30(3):217-220.
[12]	Zhao L, Li H, Guo R, et al. miR-137, a new target for post-stroke depression?[J]. Neural Regen Res, 2013, 8(26):2441-2448.
[13]	Zar M S, Shahid A A, Shahzad M S, et al. Forensic SNP Genotyping with SNaPshot: development of a novel in-house SBE multiplex SNP assay[J]. J Forensic Sci, 2018, 63(6):1824-1829. doi: 10.1111/jfo.2018.63.issue-6
[14]	Hackett M L, Yapa C, Parag V, et al. Frequency of depression after stroke: a systematic review of observational studies[J]. Stroke, 2005, 36(6):1330-1340. pmid: 15879342
[15]	Hadidi N N, Huna Wagner R L, Lindquist R. Nonpharmacological treatments for post-stroke depression: an integrative review of the literature[J]. Res Gerontol Nurs, 2017, 10(4):182-195. doi: 10.3928/19404921-20170524-02
[16]	Ibrahimagic O C, Smajlovic D, Kunic S, et al. Post-stroke depression[J]. Mater Sociomed, 2019, 31(1):31-34. doi: 10.5455/msm.2019.31.31-34 pmid: 31213952
[17]	Tan K S, Armugam A, Sepramaniam S, et al. Expression profile of MicroRNAs in young stroke patients[J]. PLoS One, 2009, 4(11):e7689. doi: 10.1371/journal.pone.0007689
[18]	Tavakolizadeh J, Roshanaei K, Salmaninejad A, et al. MicroRNAs and exosomes in depression: potential diagnostic biomarkers[J]. J Cell Biochem, 2018, 119(5):3783-3797. doi: 10.1002/jcb.26599 pmid: 29236313
[19]	Smalheiser N R, Lugli G, Rizavi H S, et al. MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects[J]. PLoS One, 2012, 7(3):e33201. doi: 10.1371/journal.pone.0033201
[20]	杨晓煜, 史齐, 褚秀峰, 等. 卒中后抑郁模型大鼠与miR-137抑制下的Grin2A表达[J]. 中国组织工程研究, 2015, 19(24):3832-3838.
[21]	Ripke S, Sanders A R, Kendler K S, et al. Genome-wide association study identifies five new schizophrenia loci[J]. Nat Genet, 2011, 43(10):969-976. doi: 10.1038/ng.940

组别	n	性别(女/男, n)	年龄(岁)
对照组	250	149/101	67.21 ± 10.34
患者组	250	162/88	67.34 ± 10.53
χ²/t值		0.139	1.438
P值		0.889	0.231

Association between microRNA-137 Gene Polymorphisms and Ischemic Post-stroke Depression

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项目	对照组(n= 250)	患者组(n= 250)	P值
基因型(n)
TT	202	225	0.011^a
GT	44	23
GG	4	2
等位基因(n)
T	448	473	0.003
G	52	27

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