右侧小脑对卒中后失语的潜在作用：基于格兰杰因果分析的初步研究

doi:10.3969/j.issn.1006-9771.2021.12.012

Abstract

Abstract:

Objective To explore the recovery mechanism of language network among post-stroke aphasic patients by investigating the difference of whole-brain amplitude of low frequency fluctuations (ALFF) and the Granger causality analysis (GCA) between the patients and the controls.Methods From May, 2019 to May, 2021, 19 patients with aphasia after left hemispheric stroke and 17 age- and sex- matched healthy controls finished functional magnetic resonance imaging scanning. All the patients assessed with Chinese version of Western Aphasia Battery (WAB). Restplus was used for fMRI data analysis. Regions with significant difference of ALFF between groups were chosen as regions of interests (ROI) for the following GCA analysis.Results ALFF in left inferior frontal gyrus triangle (LIFGtri) and left medial frontal gyrus (LMFG) were significantly lower in the patients than in the controls. Effective connectivity from LIFGtri to LMFG and from LMFG to the right cerebellar Crus I were significantly lower in the patients. Effective connectivity from right cerebellar Crus II to LIFGtri, from right cerebellar Crus I to LMFG were significantly greater in the patients.Conclusion Unidirectional negative regulatory pathway such as LIFGtri→LMFG might be injured in post-stroke aphasia, while, connectivities between right cerebellar Crus II→LIFGtri and right cerebellar Crus I →LMFG enhanced. Right cerebellum might be the potential target for the language recovery.

Key words: post-stroke aphasia, functional magnetic resonance imaging, cerebellum, Granger causality analysis

CLC Number:

R743.3

ZHANG Xiao-tong,LI Na,CHEN Zhao-cong,LIANG Jing-feng,YU Yong,WU Hui-xiang,KANG Zhuang,QIU Wei-hong. Potential Role of Right Cerebellum in Post-stroke Aphasia: A Preliminary Study Based on Granger Causality Analysis[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(12): 1458-1463.

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References 33

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组别	n	性别(男/女,n)	年龄(岁)	病程(d)
对照组	17	12/5	45.76±7.41	67.05±38.32
病例组	19	15/4	48.63±7.50
χ²/t值			1.151
P值		0.706^a	0.258

差异脑区	MNI坐标			体素	t值
差异脑区	x	y	z	体素	t值
LIFGtri	-36	18	27	50	-7.23
LMFG	-39	21	48	26	-7.01

连接方向	脑区	MNI坐标			体素	t值
连接方向	脑区	x	y	z	体素	t值
LIFGtri→全脑	LMFG	-36	51	12	258	-4.44
全脑→LIFGtri	右侧小脑Crus II	39	-69	-45	198	4.04
LMFG→全脑	右侧小脑Crus I	21	-78	-33	202	-4.09
全脑→LMFG	右侧小脑Crus I	24	-78	-33	127	3.82

Potential Role of Right Cerebellum in Post-stroke Aphasia: A Preliminary Study Based on Granger Causality Analysis

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