《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2022, Vol. 28 ›› Issue (1): 79-89.doi: 10.3969/j.issn.1006-9771.2022.01.012
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ZHI Jincao1,ZHANG Shiwen1,HUANG Meiling1,PEI Fei2,WANG Yan2()
Received:
2021-10-08
Revised:
2021-12-27
Published:
2022-01-25
Online:
2022-02-11
Contact:
WANG Yan
E-mail:swallow1113@163.com
Supported by:
CLC Number:
ZHI Jincao,ZHANG Shiwen,HUANG Meiling,PEI Fei,WANG Yan. Risk factors during pregnancy and perinatal period for attention deficit hyperactivity disorder in children: a scoping review[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(1): 79-89.
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文献 | 国家 | 研究对象 | 年龄/岁 | 样本量 (T/C)/n | 时间 | 研究设计 | 诊断标准 | 评价工具 | 危险因素 |
---|---|---|---|---|---|---|---|---|---|
李焱等[ | 中国 | ADHD儿童 | 6~16 | 132/82 | 出生后 | 病例对照研究 | DSM-Ⅴ;儿童精神障碍调查筛查及半定式诊断检查表;WISC-IV | 一般情况调查表;父母压力指数问卷(PSI) | 母体因素:孕期生病、吸烟、酗酒 宫内因素:脐带绕颈、怀孕次数 环境因素:夫妻关系不和、家庭成员丧生 围产期意外:出生性窒息、难产 |
郭明等[ | 中国 | 四年级学生 | 9~11(10.05) | 37/596 | 出生后 | 横断面病例对照研究 | Conners问卷(家长及教师用问卷);中国精神障碍分类与诊断标准第3版 | 家庭危险因素调查表 | 母体因素:母孕期心理创伤 环境因素:家庭关系欠佳 围产期意外:分娩方式(难产/剖腹产)、孕期长短(早产/过期产) |
张碧昌等[ | 中国 | 中小学生 | 11.05 | 22/2 994 | 出生后 | 随机抽样调查 | PSQ;病史询问;智力测试;DSM-IV | 自编问卷;儿童个人及家庭社会情况调查表 | 母体因素:孕期情绪低落 环境因素:父母关系不和 |
张玉等[ | 中国 | 小学生 | 5~16(9.73±1.80) | 468/9 160 | 出生后 | 分层整群随机抽样 | 问卷筛查;诊断访谈(SNAP -IV量表);DSM-IV | 问卷;访谈 | 母体因素:母孕期身体健康状况、心理健康状况不佳、生育年龄 围生期意外:出生时健康状况 环境因素:父母关系不好 |
张丽珊等[ | 中国 | ADHD儿童 | 6~9(8.19±1.92) | 720/1 576 | 出生后 | 病例对照研究 | DSM-IV | 调查问卷 | 母体因素:母亲吸烟史、母亲产后及孕期情绪低落 环境因素:父母婚姻关系(不和、离婚) |
吴丽慧等[ | 中国 | 小学生 | 10.23 | 203/203 | 出生后 | 病例对照研究 | TRS教师用量表;PSQ;DSM-IV | 家庭因素问卷调查 | 母体因素:母亲孕期精神创伤、孕期焦虑、母亲血型 宫内因素:单双胎 环境因素:夫妻关系不和 |
高宇等[ | 中国 | 剖宫产儿童 | 14岁以下 | 226/181 | 出生后 | 病例回顾性研究 | WISC;PSQ;CBCL(家长填写);DSM | 病例生产记录 | 宫内因素:宫内窘迫、宫内发育迟缓 围产期意外:剖宫产 |
Pineda等[ | 哥伦比亚 | ADHD儿童 | 6~11 | 200/200 | 出生后 | 病例随机对照研究 | 标准化ADHD诊断 | 调查问卷(关于怀孕、分娩和新生儿期问题) | 母体因素:严重流感发作(发热、无病毒)、吸烟、酗酒 宫内因素:流产先兆 围生期意外:早产、轻微先天性畸形、新生儿癫痫发作、新生儿期住院 |
Grizenko等[ | 加拿大 | ADHD儿童 | 6~12 | 203 | 出生后 | 随机对照研究 | DSM-IV-R;儿童诊断访谈时间表第四版;CBCL;Conners 家长全球指数;Conners的全球教师指数;WISC-III | Kinney 医学和妇科问卷;McNeil-Sjöstrom 量表 | 母体因素:产前压力 |
Watkins等[ | 墨西哥 | 宫内邻苯二甲酸酯暴露儿童 | 6~11 | 221 | 出生前 | 前瞻性重复测量研究(横断面) | CPT-2;CPT-3 | 孕期母体尿样测量邻苯二甲酸酯代谢物;访谈问卷 | 环境因素:宫内接触邻苯二甲酸酯 |
9~18 | 200 | ||||||||
McCoy等[ | 瑞典 | ADHD儿童 | < 18 | 15 254 | 出生后 | 出生队列研究 | ICD-9/10标准诊断 | 多代登记;国家患者登记;医疗出生登记;教育登记;健康保险和社会研究纵向整合数据库 | 母体原因:严重精神疾病 围产期意外:低出生体质量、早产、小胎龄 |
Chu等[ | 中国 | ADHD儿童 | 6~12 | 195/212 | 出生后 | 病例对照研究 | DSM-IV-TR;WISC-III;临床总体印象严重程度评分 | 出生史记录 | 围产期意外:中度早产(胎龄33~37周)、低出生体质量(出生体质量< 2 500 g) |
Linnet等[ (2005) | 丹麦 | ADHD儿童 | 2~8(5.46) | 170/3 765 | 出生后 | 嵌套病例对照研究 | ICD-10;DSM-IV;丹麦精神病学中心登记册 | 调查问卷;丹麦精神病学中心登记;丹麦医学出生登记;劳动力市场研究综合数据库;丹麦民事登记 | 母体因素:孕期吸烟 |
Chudal等[ | 芬兰 | ADHD儿童 | 12 | 10 409/39 125 | 出生后 | 嵌套病例对照研究(队列研究) | ICD-10 | 芬兰出院登记、芬兰医疗出生登记、芬兰中央人口登记 | 母体因素:低龄(< 20岁) |
Wang等[ | 丹麦 | ADHD儿童 | 12.5 | 25 747 | 出生后 | 队列研究 | ICD-10;3岁开始随访;医院登记和处方登记 | ICD-8;ICD-10;母亲病史采集 | 宫内因素:母亲流产史 |
Linnet等[ | 丹麦 | ADHD儿童 | 12 | 834/20 100 | 出生后 | 嵌套病例对照研究 | ICD-10;ICD-8 | 丹麦精神病学中央登记、丹麦医疗出生登记、劳动力市场研究综合数据库、丹麦民事登记 | 围产期意外:早产(胎龄26~36周)、接近足月出生体质量低(1 500~2 499 g) |
Getahun等[ | 美国 | ADHD儿童 | 5~11 | 13 613/295 021 | 出生后 | 嵌套病例对照研究 | 随访期间接收了≥2张针对ADHD的处方 | 围产期服务系统记录、住院和门诊就诊记录;ICD-9-CM医疗记录 | 围产期意外:出生窒息、呼吸窘迫综合征、先兆子痫 |
Hanć等[ | 美国 | ADHD儿童 | 6~18 | 132/146 | 出生后 | 病例对照研究(分级评估) | 访谈;ICD-10;DSM-IV-TR | 医疗登记处收集信息(胎儿、孕妇);父母问卷;新生儿健康评估(Apgar评分、出生时间和出生体质量); | 围产期意外:Apgar评分下降、低出生体质量 |
Sucksdorff等[ | 芬兰 | ADHD儿童 | < 2 | 10 321/38 355 | 出生后 | 嵌套病例对照研究 | ICD-9;ICD-10;DSM-IV | 芬兰医疗出生登记、芬兰医院出院登记、芬兰中央人口登记 | 围产期意外:妊娠期短、早产 宫内因素:胎儿发育不良 |
Sourander等[ | 芬兰 | ADHD儿童 | 7.3 | 1 079/1 079 | 出生前 | 病例对照研究 | ICD-8;ICD-10;DSM-IV | 母亲孕期血清中可替宁水平;芬兰医疗出生登记、芬兰医院出院登记册、芬兰中央人口登记 | 环境因素:尼古丁暴露 |
Chen等[ | 中国 | ADHD儿童 | 5 | 950/3 800 | 出生后 | 病例对照研究 | ICD-9-CM | 母亲乙酰氨基酚的使用情况 | 母体因素:乙酰氨基酚暴露 |
Modesto等[ | 荷兰 | 正常儿童 | 5~8 | 3 873 | 出生前 | 出生队列研究 | Conners家长评分量表修订版;诊断性访谈 | 妊娠13.6周母体甲状腺激素水平;调查问卷和医疗记录提取信息 | 母体因素:低甲状腺素血症(宫内暴露于甲状腺激素水平不足) |
Wolford等[ | 芬兰 | 正常儿童 | 3~6(3.8) | 1 779 | 出生前 | 前瞻性队列研究 | Conners多动指数(母亲填写);CBCL | BMI;抑郁量表;贝克抑郁量表-II;医疗记录提取母亲妊娠疾病(妊娠糖尿病、妊娠高血压) | 母体因素:孕期母亲抑郁症状 |
Rodriguez[ | 瑞典 | 正常儿童 | 5 | 1 714 | 出生前 | 前瞻性妊娠-后代队列研究 | DSM-IV;父母老师填写优势与困难问卷情绪评分 | 瑞典医学出生登记;母亲:生活事件压力调查问卷、爱丁堡产后抑郁量表、成人ADHD自我报告量表、DSM-IV | 母体因素:产前超重或肥胖 |
Chen等[ | 中国 | 正常儿童 | 6.5 | 708 515 | 出生后 | 出生队列研究 | ICD-9-CM | 5个时期(怀孕前、怀孕期间和分娩后< 1、1~3和> 3年)评估父母亲抑郁症 | 母体因素:母亲抑郁 环境因素:父亲抑郁 |
Fuemmeler等[ | 美国 | 正常儿童 | 2~6 | 331 | 出生后 | 出生队列研究 | 儿童行为评估系统;第二版学龄前家长评定量表;执行功能行为评定量表 | 孕前BMI;成人ADHD自我报告量表 | 母体因素:孕期母亲体质量增加(孕前BMI ≥ 35 kg/m2) |
Morales等[ | 西班牙 | 正常儿童 | 4~5(4.8) | 1 650 | 出生前 | 前瞻性出生队列研究 | DSM-IV;儿童调查问卷(老师填写) | 妊娠13周时25-羟基维生素D3的血浆浓度;调查问卷(母亲妊娠晚期填写) | 母体因素:维生素D低 |
Shih等[ | 中国 | 正常儿童 | 8 | 374/16 002 | 出生前 | 前瞻性纵向队列研究 | 医生和专家评估(未明确描述) | 台湾出生登记;结构化问卷调查;台湾空气质量监测网站;儿童6个月时与家长面对面访谈 | 环境因素:NO暴露 |
Mikkelsen等[ | 芬兰 | 正常儿童 | 5~16 | 295 687 | 出生后 | 队列研究 | ICD-10 | Apgar评分;脐动脉脐带pH值;芬兰全国登记 | 围产期意外:出生窒息 |
Rodriguez等[ | 瑞典丹麦芬兰 | 学龄前儿童 | 7~8 (SE、FI) 10~12 (DK) | 12 556 | 出生前 | 前瞻性妊娠队列研究 | 瑞典和丹麦:优势与困难问卷;芬兰:Rutter量表 | 医疗记录和问卷;母亲自我报告问卷 | 母体因素:母亲肥胖或超重 |
Nomura等[ | 美国 | 学龄前儿童 | 3~4 | 212 | 出生后 | 队列研究 | ADHD评定量表-IV;情感障碍和精神分裂症时间表;初级智力量表第三版;儿童气质评估修订版;儿童行为评估系统-2;家长和教师评定量表;发育神经心理学评估 | 社会经济声望指数;访谈 | 母体因素:妊娠期糖尿病 环境因素:低社会经济地位 |
Huizink等[ | 芬兰 | 宫内焦虑暴露双胞胎儿童 | 14 | 232/572 | 出生前 | 前瞻性队列对照研究 | 青少年酗酒遗传学半结构化评估;DSM-III-R | 暴露于1986年4月切尔诺贝利灾难(压力源) | 母体因素:孕期焦虑暴露 |
Hack等[ | 美国 | 极低出生体质量儿童 | 8 | 219/176 | 出生后 | 队列对照研究 | CSI-4(家长填写);DSM-IV | 出生记录 | 围产期意外:极低出生体质量(出生体质量< 1 kg) |
Perricone等[ | 意大利 | 早产儿 | 5.2 | 50/50 | 出生后 | 对照研究 | 教师早期ADHD检测问卷;DSM-IV;Kendall and Wilcox量表;父母ADHD早期检测问卷 | 问卷调查儿童出生基本信息(家长和儿童) | 围产期意外:中度早产(< 36周) |
Morrow等[ | 美国 | 可卡因暴露儿童 | 5 | 208/192 | 出生前 | 前瞻性队列对照研究 | DSM-IV;儿童计算机诊断访谈计划 | 产妇访谈;生物标志物检测(母婴尿液和胎粪);巴拉德胎龄评估;血铅水平 | 母体因素:可卡因暴露 |
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