下肢截肢患者的脑功能连接

doi:10.3969/j.issn.1006-9771.2022.01.013

Abstract

Abstract:

Objective To investigate the changes of functional brain connectivity over multiple frequency bands in resting-state electroencephalography (EEG) for lower limb amputation patients. Methods Resting-state EEG was collected from 18 lower limb amputees and 22 healthy controls from November, 2020 to June, 2021. Functional connectivity matrix was constructed with phase-locked values (PLV), and compared between groups. Results The functional connectivity was weaker in the amputees than in the controls on α band (t = 3.433, P = 0.001) and β band (t = 3.806, P = 0.001), and there was no significant difference on δ band (t = 1.429, P = 0.161) and θ band (t = 1.211, P = 0.233). Conclusion EEG functional connectivity weakens in lower limb amputees in on the α and β band, which results in neuroplasticity of multiple brain regions, not only for limb-respond cortex, but also for frontal, temporal and occipital cortices.

Key words: lower limb, amputation, resting-state electroencephalography, functional connectivity, phase-locked values

CLC Number:

R687.5

LIU Shaowen,WEI Conghui,SHAN Xinying,ZHANG Yan. Brain functional connectivity in lower limb amputees[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(1): 90-94.

Figures/Tables 5

References 29

[1]	STRIEM-AMIT E. Brain plasticity: when the feet and mouth replace the hand[J]. Curr Biol, 2017, 27(9):356-358.
[2]	VON BERNHARDI R, BERNHARDI L E, EUGENÍN J, et al. What is neural plasticity?[J]. Adv Exp Med Biolo, 2017, 1015:1-15.
[3]	张静娜. 下肢截肢后幻肢痛患者大脑结构和功能MRI研究[D]. 重庆:中国人民解放军陆军军医大学, 2019.
	ZHANG J N. An MRI study of brain structure and function in patients with PLP after lower limb amputation[D]. Chongqing: Army Medical University, 2019.
[4]	DI PINO G, GUGLIELMELLI E, ROSSINI P M, et al. Neuroplasticity in amputees: main implications on bidirectional interfacing of cybernetic hand prostheses[J]. Prog Neurobiol, 2009, 88(2):114-126. doi: 10.1016/j.pneurobio.2009.03.001
[5]	XIE H, KANE J T, DENNIS M J, et al. Case series evidence for changed interhemispheric relationships in cortical structure in some amputees[J]. J Clin Neurosci, 2013, 20(4):523-526. doi: 10.1016/j.jocn.2012.03.043
[6]	HASHIM E, ROWLEY C D, GRAD S, et al. Patterns of myeloarchitecture in lower limb amputees: an MRI study[J]. Front Neurosci, 2015, 9:15.
[7]	JIANG G, YIN X, LI C, et al. The plasticity of brain gray matter and white matter following lower limb amputation[J]. Neural Plast, 2015, 2015:823185.
[8]	HERTA F, MARTIN D, JAMILA A, et al. The neural basis of phantom limb pain[J]. Trend Cogn Sci, 2013, 17(7):307-308. doi: 10.1016/j.tics.2013.04.007
[9]	MAKIN T R, FILIPPINI N, DUFF E P, et al. Network-level reorganisation of functional connectivity following arm amputation[J]. NeuroImage, 2015, 114:217-225. doi: 10.1016/j.neuroimage.2015.02.067
[10]	ZHANG J, ZHANG Y, WANG L, et al. Brain functional connectivity plasticity within and beyond the sensorimotor network in lower-limb amputees[J]. Front Hum Neurosci, 2018, 18:403-413.
[11]	HAHAMY A, MACDONALD S N, VAN DEN HEILIGENBERG F, et al. Representation of multiple body parts in the missing-hand territory of congenital one-handers[J]. Curr Biol, 2017, 27(9):1350-1355. doi: 10.1016/j.cub.2017.03.053
[12]	MAHON B Z, CARAMAZZA A. What drives the organization of object knowledge in the brain?[J]. Trend Cogn Sci, 2011, 15(3):97-103. doi: 10.1016/j.tics.2011.01.004
[13]	DANIELE N, ELENA D, FRANÇOIS R, et al. Left and right hand recognition in upper limb amputees[J]. Brain, 2004, 127(1):120-132. doi: 10.1093/brain/awh006
[14]	MAKIN T R, SCHOLZ J, FILIPPINI N, et al. Phantom pain is associated with preserved structure and function in the former hand area[J]. Nat Commun, 2013, 4(1):1693-1710. doi: 10.1038/ncomms2700
[15]	SANTAMARIA L, JAMES C. Classification in emotional BCI using phase information from the EEG[J]. Annu Int Conf IEEE Eng Med Biol Soc, 2016, 2016:371-374.
[16]	李昭阳, 龚安民, 伏云发. 基于EEG脑网络下肢动作视觉想象识别研究[J]. 南京大学学报(自然科学), 2020, 56(4):570-580.
	LI Z Y, GONG A M, FU Y F. Identification of visual imagery of movements involving the lower limbs based on EEG network[J]. J Nanjing Univ (Nat Sci), 2020, 56(4):570-580.
[17]	王玲, 陈楠. 运动想象对脊髓损伤患者大脑活动和脑网络重塑MR研究进展[J]. 中国医学影像技术, 2019, 35(10):1586-1589.
	WANG L, CHEN N. MRI research progresses of motor imagery on brain activity and network reorganization in patients with spinal cord injury[J]. Chin J Med Imaging Technol, 2019, 35(10):1586-1589.
[18]	施锦河, 沈继忠, 王攀. 四类运动想象脑电信号特征提取与分类算法[J]. 浙江大学学报(工学版), 2012, 46(2):338-344.
	SHI J H, SHENG J Z, WANG P. Feature extraction and classification of four-class motor imagery EEG data[J]. J Zhejiang Univ (Eng Sci), 2012, 46(2):338-344.
[19]	LÜ Y Y, GUO X L, WANG Z, et al. Resting-state EEG network change in alpha and beta bands after upper limb amputation[C]. Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2016.
[20]	DELORME A, MAKEIG S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis[J]. J Neurosci Method, 2004, 134(1):9-21. doi: 10.1016/j.jneumeth.2003.10.009
[21]	DIERSSEN M, RAMAKERS G J A. Dendritic pathology in mental retardation: from molecular genetics to neurobiology[J]. Gene Brain Behav, 2006, 5(2):48-60. doi: 10.1111/gbb.2006.5.issue-s2
[22]	PREIßLER S, DIETRICH C, BLUME K R, et al. Plasticity in the visual system is associated with prosjournal use in phantom limb pain[J]. Front Hum Neurosci, 2013, 7:311-320.
[23]	JIANG G, LI C, WU J, et al. Progressive thinning of visual motion area in lower limb amputees[J]. Front Hum Neurosci, 2016, 10:79. doi: 10.3389/fpsyg.2019.00079
[24]	INANAGA K. Frontal midline theta rhythm and mental activity[J]. Psychiatry Clin Neurosci, 1998, 52(6):555-566. doi: 10.1111/j.1440-1819.1998.tb02700.x
[25]	PAWELA C P, BISWAL B B, HUDETZ A G, et al. Interhemispheric neuroplasticity following limb deafferentation detected by resting-state functional connectivity magnetic resonance imaging (fcMRI) and functional magnetic resonance imaging (fMRI)[J]. NeuroImage, 2010, 49(3):2467-2478. doi: 10.1016/j.neuroimage.2009.09.054
[26]	DIRK D R, ANA B E, RANULFO R, et al. Phantom percepts: tinnitus and pain as persisting aversive memory networks[J]. Proc Natl Acad Sci U S A, 2011, 108(20):8075-8080. doi: 10.1073/pnas.1018466108
[27]	ELBERT T, FLOR H, BIRBAUMER N, et al. Extensive reorganization of the somatosensory cortex in adult humans after nervous system injury[J]. Neuroreport, 1994, 5(18):2593-2597. doi: 10.1097/00001756-199412000-00047
[28]	FLOR H, ELBERT T, KNECHT S, et al. Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation[J]. Nature, 1995, 375(6531):482-484. doi: 10.1038/375482a0
[29]	MACIVER K, LLOYD D M, KELLY S, et al. Phantom limb pain, cortical reorganization and the therapeutic effect of mental imagery[J]. Brain, 2008, 131(8):2181-2191. doi: 10.1093/brain/awn124

患者	性别	年龄/岁	截肢部位	病程/月	病因
1	女	57	小腿	8	交通事故
2	男	46	大腿	4	交通事故
3	男	41	小腿	7	交通事故
4	男	49	小腿	24	交通事故
5	男	49	大腿	14	交通事故
6	男	53	大腿	5	烧伤
7	男	33	大腿	6	交通事故
8	男	52	小腿	2	感染
9	女	66	大腿	8	交通事故
10	男	35	小腿	2	感染
11	男	46	小腿	19	交通事故
12	男	32	小腿	2	交通事故
13	男	34	小腿	19	电击伤
14	男	57	小腿	8	感染
15	男	62	大腿	13	交通事故
16	男	45	大腿	17	交通事故
17	男	44	大腿	20	肿瘤
18	男	50	小腿	5	交通事故

Brain functional connectivity in lower limb amputees

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组别	n	δ	θ	α	β
对照组	22	0.70±0.02	0.56±0.02	0.51±0.03	0.46±0.03
患者组	18	0.70±0.02	0.55±0.02	0.47±0.03	0.42±0.04
t值		1.429	1.211	3.433	3.806
P值		0.161	0.233	0.001	0.001

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