《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2022, Vol. 28 ›› Issue (7): 797-802.doi: 10.3969/j.issn.1006-9771.2022.07.009

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A novel wearable transcutaneous tibial nerve stimulator inhibits bladder reflexes in cats

LIANG Yanan1,2a,HE Panqi1,2a,LIAO Limin1,2,a2,b3()   

  1. 1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
    2. a. Department of Urology; b. Department of Neurourology, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
    3. Department of Urology, Capital Medical University, Beijing 100068, China
  • Received:2021-12-01 Revised:2022-02-07 Published:2022-07-25 Online:2022-08-08
  • Contact: LIAO Limin E-mail:lmliao@263.net
  • Supported by:
    China Rehabilitation Research Center Young Fund(2020-Q9);National Key Research and Development Project(2018YFC2002203)

Abstract:

Objective To observe the inhibitory effects of a novel wearable transcutaneous tibial nerve stimulator on bladder reflex in cats under different stimulation parameters.

Methods A total of 18 cats were divided into intensities, frequencies and waveforms groups, which wore the stimulator on the ankles and stimulated in different threshold (T) intensities (1/2 T, 1 T, 3/2 T and 2 T), frequencies (5 Hz, 10 Hz, 15 Hz and 30 Hz) and waveforms (A and B). The cats were anesthetized and infused normal saline to induce bladder reflex, while the bladder capacity was measured. Cystometrograms were compared among stimulation parameters.

Results The bladder capacity was not significantly different among the intensities (F = 1.997, P = 0.126), while the bladder capacity was more after TNS of 3/2 T and 2 T than baseline (P < 0.05). The bladder capacity was significantly different among the frequencies (F = 3.894, P = 0.014), while the bladder capacity was more after 5 Hz, 10 Hz and 15 Hz of TNS (P < 0.05). The bladder capacity was significantly different between the waveforms (F = 5.184, P = 0.019), while the bladder capacity was more after waveform A of TNS than baseline (P < 0.05).

Conclusion The novel wearable transcutaneous tibial nerve stimulator can effectively inhibit the physiological bladder reflex in cats, which associates to the intensity, frequency and waveform of stimulation.

Key words: tibial nerve stimulation, overactive bladder, frequency, intensity, waveform, cats

CLC Number: