Abstract: 20 patients with paralysis at thoracic or lumbar level were randomly divided into twogroups. Patients in the lst group receive thiopental, pancuronium, fentanyl in small dose and nifedipine10mg before intubation.Patients in the 2nd group receive thiopental and pancuronium. Hemodynamic indices and serum catecholamine concentrations were measured at different time intervals pre and post-intubation.The results show that each variables of hemodynamic indices and serum concentration in the lst groupare approximate or lower than the values of pre--intubation,but each value of the 2nd group at post--intubation increase significantly.The study demonstrated that nifedipine and fentanyl in small dosage may effectively ameliorate thestress response during intubation.

Key words: endotracheal intubation, stress, nifedipine, fentanyl