CJRTP

《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2002, Vol. 8 ›› Issue (05): 294-295.

• 专题研究 • Previous Articles     Next Articles

Investigation of the interaction of polyamidoamine dendrimers with nicotinic acid as solubility enhancer

YE Ling1; GU Wei1; BAI Jing fa1; ZOU Jing xun1; YANG Hua1; PIAO Dong xu2   

  1. 1.Department of Chemistry,Capital University of Medical Sciences,China, Beijing 100054;2.China Rehabilitation Research Center,China,Beijing 100077
  • Received:2002-03-05 Published:2002-05-25 Online:2002-05-25

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Abstract: ObjectivePolyamidoamine(PAMAM) dendrimers enhance the solubility of nicotinic acid. MethodsPAMAM dendrimers of generation 1 to 6 were prepared and the effect of pH and concentration of the dendrimers on the solubility enhancement of nicotinic acid was investigated. ResultsThe pH and concentration of the dendrimers influence the solubility enhancement of nicotinic acid. Conclusions Electrostatic interaction between the carboxyl group of the nicotinic acid and the amine groups of the dendrimers is involved.

Key words: nicotinic acid, PAMAM dendrimer, solubility enhancement