Abstract: ObjectiveTo study the effects of painful inter-stimulus interval on event-related potentials in rabbits for best inter-stimulus interval.MethodsElectrode was attached to F4 site on rabbits' skull. An Oddball paradigm stimulus were adopted. The waveforms recorded under different inter-stimulus interval were analysed.ResultsThe latency of pain evoked potentials P2,N2,P3a under different inter-stimulus interval showed no significant difference.The amplitude was highest when the interval was 8s.ConclusionsThere is a best inter-stimulus interval for pain evoked potential.

Key words: inter-stimulus interval, evoked potentials, pain, rabbits