Abstract: ObjectiveTo analyze the relationship of depression after stroke with the location of lesion and the leve l of central nervous system (CNS) damage, and evaluate the treatment effect.Methods86 stroke patients were evaluated by Zung's self-rating depression scale (SDS). If SDS score ≥50 points, the patient was s elected as subjects for this study and treated with fluoxetine. The relationship of depression with the location of lesion and the level of CNS damage, and the treatment effect were analyzed.ResultsThere were 3 4 cases evaluated as depression (with 27 light depressive cases, 7 moderate depr essive and severe depressive cases). The symptom of depression has a positive co rrelation to the damage level (P<0.05). The depression inci dence of patients with acute sub-cortex stroke is higher than that of cerebral cortex and cerebellum stroke (P<0.01). Fluoxetine has a goo d effect on depression after stroke.Conclusions Th e symptom of depression after stroke has a positive correlation to the damage le vel. Fluoxetine has a good effect on depression after stroke.

Key words: stroke, depression, fluoxetine