《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2004, Vol. 10 ›› Issue (05): 281-282.

• 基础研究 • Previous Articles     Next Articles

Synthesis and structure of the Salen-Mn compound

GUO Jin-lan, ZHANG Cheng-bo   

  1. Institution of Rehabilitation Medicine, Chinese Rehabilitation Research Centre, Beijing 100068, China
  • Received:2003-12-01 Published:2004-05-25 Online:2004-05-25

Abstract: ObjectiveTo synthesize metal complex that exhibits superoxide dismutase (SOD)-like activity and determine its structure.MethodsThis chemical compound was synthesized by means of reflux in laboratory.Its structure was examined by infrared spectra (IR),nuclear magnetic resonance hydrogen spectra(H-NMR) and mass spectra (MS).The activity of the SOD was determine by xanthine oxidase (XOD).ResultsThe IR indicted that this complex showed a typical absorption band of -OH,C=N and benzene. The H-NMR reveals the existence of metal ion manganese (Mn3+ ,paramagnetic). The molecular weight was 365, which was obtained by EI-MS analysis. And this complex showed SOD-like activity.ConclusionA metal complex with low molecular weight and SOD-like activity has been synthesized.

Key words: superoxide dismutase(SOD), free radical, complex synthesis