Abstract: ObjectiveTo investigate the effect of Jiuqiang Naoliqing(JNQ) on the TXA₂ and PGI₂ level in spontaneous hypertension rat (SHR) plasma.MethodsThe plasma was separated after the SHR and Wistar rats were treated with JNQ at the dose of 0.133g/kg,0.265g/kg,0.530g/kg and 1% carboxymethyl cellulose respectively for 5 weeks. The level of TXB₂ and 6 keto PGF_1α ,stable metabolin of TXA₂ and PGI _{2,in SHR plasma was tested by radioimmunoassay.ResultsThe level of TXB2 and the ratio of TXB2/6 keto PGF1α (T/P) in SHR plasma increased significantly(P<0.01),and there was no significant difference in the concentration of 6 keto PGF1α between Wistar rats and SHR plasma(P>0.05). JNQ could increase the generation of 6 keto PGF1α and decrease the level of TXB2 and T/P in SHR plasma after treated with different dosages for 5 weeks.ConclusionJNQ may improve the balance between TXA2 and PGI2 in SHR plasma.}

Key words: Jiuqiang Naoliqing, spontaneous hypertension rat(SHR), thromboxane A₂(TXA₂), prostaglandin I₂(PGI₂)