Abstract: ObjectiveTo observe the effect of patient controlled analgesia (PCA) of with tramadol intravenous and epidural injection after prostate operation.Methods90 patients undergoing prostatectomy were randomly divided into intravenous PCA group (PCIA), epidural PCA group (PCEA) and control group (not using easy pain drug), with 30 cases in each group. The loading dose of tramadol was 1 mg/kg. The severity of pain, incidence of nausea and vomiting, total dosage of tramadol used in 24 h ,and patient's satisfaction were assessed.ResultsThe postoperative pain scores of PCIA group were significantly lower than that of PCEA group. Between two groups, there were no significant differences in the overall satisfaction of pain relief, sedation and vomiting.ConclusionPCA with tromadol is safe and effect after prostate operation, and the effect of intravenous PCA is better than that of epidural PCA.

Key words: prostatectomy, tramadol, intravenous injection, epidural injection