Abstract: ObjectiveTo investigate the feasibility of transcranial Doppler (TCD) in evaluating the effect of drugs on reducing the intracranial pressure.Methods20 patients who were treated with 20% mannitol (10 cases) and 10% glycerin (10 cases) separately were monitored the changes of blood flow velocity of middle cerebral artery (MCA) with TCD before and after treatment. ResultsIn mannitol group, The peak time presented at 30 min (P<0.001) after drug application and continued 4～6 h after treatment. In glycerin group, the peak time presented at 2 h (P<0.001) after drug application and continued 6～8 h after treatment.ConclusionTCD can monitor the changes of of blood flow velocity of middle cerebral artery (MCA) and thereby evaluate the effects of drugs on reducing intracranial pressure.

Key words: transcranial Doppler, intracranial hypertension, cerebral blood flow, drug evaluation