《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2005, Vol. 11 ›› Issue (08): 626-627.

• 基础研究 • Previous Articles     Next Articles

Effect of arsenic trioxide on the expressions of human gastric cancer genes nm23 and P53

DAI Ya-hong, LIUShu-mei, MENGXin,et al   

  1. The Department of Digestion, The Frist Affiliated Clinical Hospital of Harbin Medical University, Harbin 150001,Heilongjiang, China
  • Received:2004-10-18 Published:2005-08-25 Online:2005-08-25

Abstract: ObjectiveTo detect the effect arsenic trioxide (As2O3) on the expressions of human gastric cancer genes nm23 and P53.MethodsThe expressions of proteins coded by nm23 and P53 were examined with immunohistochemistry method after treated by As2O3.ResultsThe expressions of proteins coded by nm23 and P53 decreased after treated by As2O3 (P<0.05).ConclusionAs2O3 can down-regulate the expressions of proteins coded by nm23 and P53.

Key words: arsenic trioxide (As2O3), gene expression, cancer