Abstract: ObjectiveTo explore the pathogeny, diagnosis and rehabilitation of central pontine myelinolysis.MethodsClinical data of four patients with central potine myelinolysis were studied retrospectively.ResultsAll of them had pseudobulbar palsy and dystonia; three had coma; two had history of hyposodemia ameliorated rapidly, one had history of hypersodemia ameliorated rapidly. All of them had focuses in pons; three had focuses beyond pons. All patients had good prognoses.ConclusionHistory of hyposodemia ameliorated rapidly is a usual pathogeny of central potine myelinolysis, integrative measures of rehabilitation can improve prognosis and quality of daily life.

Key words: central pontine myelinolysis (CPM), magnetic resonance imaging (MRI), rehabilitation