《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2005, Vol. 11 ›› Issue (11): 924-926.
• 基础研究 • Previous Articles Next Articles
ZHAO Xiao-yuan, ZUO Ping-ping, DUAN Jin-hong,et al
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Abstract: ObjectiveTo investigate the effect of α-Zearalanol(α-ZAL) on lipometabolism and hemorheology in ovariectomized(OVX) hyperlipidemia rabbits.Methods44 adult virgin female rabbits were divided into 5 groups,group A: normal control;group B: sham+CHO;group C: OVX+CHO;group D: OVX+CHO+17βE_2;group E: OVX+CHO+α-ZAL.Cholesterol(CHO) was fed to rabbits for 12 weeks.Before and after feeding CHO,the serum lipid(TC,TG,LDL-C,HDL-C) were measured;Blood viscosity,plasma viscosity,aggregation index of RBC(AIRC) and fibrinogen were also assayed respectively.ResultsThe serum levels of TC,TG and LDL-C in group B and E were significantly decreased compared with those in group C(P<0.05);the level of blood viscosity,plasma viscosity and AIRC platelet aggregation rate in group D and E were also significantly decreased compared with those in group C(P<0.05).Conclusionα-ZAL can improve vascular function through the adjustment of lipometabolism and hemorheology.
Key words: phytoestrogen, hyperlipidemia, lipometabolism, hemorheology, α-Zearalanol
ZHAO Xiao-yuan;ZUO Ping-ping;DUAN Jin-hong;et al. Influence of α-Zearalanol on lipometabolism and hemorheology in experimental hyperlipidemia rabbits [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2005, 11(11): 924-926.
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