《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2005, Vol. 11 ›› Issue (11): 927-928.
• 基础研究 • Previous Articles Next Articles
HAN Xue-feng, ZHU Yun-long, CHEN Chen
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Abstract: ObjectiveTo investigate the in vitro effect of ghrelin on membrane membrane potentail of GH3 cells.MethodsNystatin-perforated whole-cell recording configuration was used.ResultsThe membrane potentail of GH3 was decreased from-(72±4.78) mV to(54.8±4.58) mV(P<0.01) after application of ghrelin(10-7～10-8 M)ConclusionGhrelin can transiently and significantly decreased the amplitude of membrane potentail,which may contribute to the ghrelin-stimulated GH secretion from GH3 cells.
Key words: ghrelin, patch-clamp, membrane potentail, growth hormone
HAN Xue-feng;ZHU Yun-long;CHEN Chen. Reduction of membrane potential in GH3 cells with ghrelin [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2005, 11(11): 927-928.
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