Abstract: ObjectiveTo observe the changes of neonatal behavior neurological assessment (NBNA) and one year intellectual quotient in newborn with hypoxic ischemic encephalopathy after early intervention of rehabilitation.MethodsEighty newborns with apnea combined with hypoxic ischemic encephalopathy were divided randomly into routine group and early rehabilitation group with 40 cases in each group. Newborns in early rehabilitation group received rehabilitation treatment. All children were tested once with Chinese 20 terms NBNA before treatment and after 1 course treatment. After one-year following-up, Gesell preliminary assessment was used to test children's four items of intellectual development quotients, including abilities of action, responding to object, responding to human, and language.ResultsAfter treatment, NBNA scores of children in early rehabilitation group were significantly higher than that in routine group (P<0.01), and cases that NBNA scores over 35 in early rehabilitation group were more than that in routine group (P<0.05). After one-year following-up, the scores of intellectual development quotient of children in early rehabilitation group increased significantly compared with that in routine group (P<0.05).ConclusionEarly rehabilitation can raise NBNA sores and intellectual development quotient after one year in neonate with hypoxic ischemic encephalopathy.

Key words: newborn, hypoxic ischemic encephalopathy, early rehabilitation