Abstract: ObjectiveTo investigate the clinical features of 19 patients with opticospinal multiple sclerosis(OSMS).Methods19 cases with OSMS according to Kira Criteria were collected(15 women).Their clinical features were analyzed in combination with the laboratory examination.Results and ConclusionThere was no significant difference in the aspects of age of onset,disease duration,initial symptoms,MRI finding,evoked potential,immunological test of cerebrospinal fluid(CSF),between literatures reported elsewhere and ours. However,in our study,the OSMS patients did not show CSF pleocytosis associated with a decreased protein levels.The proportion of OSMS in all the types of MS seemed to be lower(18.66%).

Key words: multiple sclerosis, opticospinal multiple sclerosis(OSMS), diagnosis