《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2006, Vol. 12 ›› Issue (11): 954-956.

• 基础研究 • Previous Articles     Next Articles

Repairing of Spinal Cord Injury with Schwann Cell Neurilemma Channel in Rats

NAN Feng, LI Jing-nian, DONG Jian-li, et al   

  1. The Second Affiliated Hospital, Dalian Medical University, Dalian 116027, Liaoning, China
  • Received:2006-05-29 Published:2006-11-01 Online:2006-11-01

Abstract: ObjectiveTo apply the Schwann cell neurilemma channel(SCNC) in promoting the regeneration of injuried spinal cord.MethodsSpinal cords of rats after laminectomy at T8/9 were divided in 3 groups randomly: 10 rats were transplanted with SCNC(Group A);10 rats only made models(Group B);10 rats were as normal control group(Group C).All rats received behaviour survey and inclined plane test every week 8 weeks after operation.6 weeks after operation,they were measured with cortical somatosensory evoked potential(CSEP).And 8 weeks after operation,all specimens were studied histologically.ResultsCSEP could be recorded in group A and C,but not in group B.There were marked differenties between group A or C and group B in behavior survey,inclined plane test.Amount of nerve fibers regenerated through the injury gap in group A was significantly larger than that in group B.ConclusionSCNC could facilitate axonal regeneration and promote the repairing of injuried spinal cord.

Key words: Schwann cell neurilemma channel(SCNC), spinal cord injury, rats