Abstract: Agitation, aggression and depression are frequent neurobehavioral sequalae after injury of brain. These behavioural symptoms disrupted patient care and impede rehabilitation effort. In severe cases, the patient even hurts others and sometime injuries himself. This article introduces the use of antipsychotics, mood stablizing, lithium, antianxiety medication and antidepressants especially the SSRIs for the emotion disturbance after injury of brain. Meantime, paper describes the 5-HT syndrome, withdrawal 5-HT syndrome, the neuroleptic malignant syndrome (NMS). The later is owing to wrong use of phenothiazines and butyrophenones. The mortality of NMS is about 25%, if case treats is not correct.

Key words: brain injury, emotional disturbance, drug rehabilitation