Abstract: Parkinson's disease (PD) is one of the prevalent neurodegenerative diseases in human being, which is characterized by the selective degeneration and death of dopaminergic neurons in the substantia negra. The etiology of PD is not illuminated yet. Currently this disease is thought to be the result of the co-operation of multiple factors. So far, PD can't be cured, and all the treatments are to control its symptoms. DA, PDI, Parkin gene, PINK1 gene and α-synuclein are all related to PD. Apoptosis may play a role in the degeneration and death of dopaminergic neurons. Disfunction of mitochondria appears to play a role in the pathogenesis of PD. The levels of CoQ10 from PD patients have been reported to be lower than that from normal people, and the supplement of CoQ10 favors the assistant treatment of PD.

Key words: Parkinson's disease, diagnosis, treatment, gene, mitochondria, CoQ10, review