Abstract: Objective To observe the effect of Risperdal combined with occupational therapy on chronic schizophrenia.Methods 30 patients with chronic schizophrenia,who treated by Risperdal with adequate dose and sufficient course but still had negative symptoms,received a 12-week occupational therapy training(the dosage of Risperdal not changed).The patients were assessed using Scale for the Assessment of Negative Symptom(SANS)and In-patient Rehabilitation Rating Scale(IPROS)before and after occupational therapy.Results After occupational therapy,patients' SANS scores decreased significantly(P<0.01),and social function improved significantly(P<0.05).Conclusion Risperdal combined with occupational therapy can further improve the negative symptoms of patients with chronic schizophrenia and promote their social function.

Key words: occupational therapy, Risperdal, chronic schizophrenia