p75基因与2型糖尿病大鼠脑细胞凋亡相关性研究

Abstract

Abstract: Objective To study the relationship between expression of p75 gene and apoptosis of cerebrum cells in type 2 diabetic rats.Methods Ten type 2 diabetic rats and ten natural rats were used to test the expression of brain p75 mRNA by RT-PCR technique, and the apoptosis of cerebrum cells was measured by agarose gel electrophoresis (AGA).Results The expression of brain p75 mRNA and apoptosis of cerebrum cells in type 2 diabetic rats were higher than that of the natural group.Conclusion The apoptosis of cerebrum cells in type 2 diabetic rats increases, and it is positively correlated with the expression of brain p75 gene mRNA.

Key words: type 2 diabetic rat, p75 gene, apoptosis

REN Feng-yun;ZONG Can-hua;LV Xiu-fang;et al. Relationship between Expression of p75 Gene and Apoptosis of Cerebrum Cells in Type 2 Diabetic Rats [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2008, 14(06): 533-534.

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Relationship between Expression of p75 Gene and Apoptosis of Cerebrum Cells in Type 2 Diabetic Rats

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