Abstract: Estrogen is an important active endogenous substance which is needed by female to sustain normal psychological and physiological function.Studies have demonstrated that estrogen has an extensive effect on the central nervous system.This review explained the relation between estrogen and learning on a few aspects such as neurobiochemistry,neurophysiology,neuroanatomy,signal transduction and so on.

Key words: estrogen, learning and memory, neurobiochemistry, neurophysiology, neuroanatomy, signal transduction, review