Abstract: Objective To evaluate the relationship between the early renal injury and the pulse pressure or pulse pressure index in hypertension patients. Methods The pulse pressure (PP) and the pulse pressure index (PPI) in 96 patients with mild to moderate essential hypertension were calculated and the urine β₂-microglobulin (β₂-MG), the urine α₁-microglobulin (α₁-MG), albumin were detected.Results The urine β₂-MG, the urine α₁-MG and albumin in patients with PP>65 mmHg were higher than those with PP≤65 mmHg （P<0.05）; The urine β₂-MG and the α₁-MG, albumin in patients with PPI>0.5 were higher than those with PPI≤0.5 （P<0.05）. While the patients with renal injury complicated with a higher PP or PPI than those without renal injury （P<0.05）. Conclusion The renal injury is more severe in patients with higher pulse pressure and pulse pressure index.

Key words: hypertension, pulse pressure, pulse pressure index, renal injury