Abstract: Neuropathic pain is an intractable pain condition that initiated or caused by a primary lesion or dysfunction in the nervous system. Because the underlying molecular mechanisms of neuropathic pain are largely unknown, routine pharmacologic treatment is often insufficient. It has become a rather tough problem bothering both physicians and patients. Recently, with the development of molecular biology, the study of neuropathic pain stepped into the post-genomic period which is characterized by study of proteome. A number of proteomic studies have been performed using different animal neuropathy models. The Results of these proteomic approaches are summarized in this review to provide a better overview of proteins that are involved in the mechanisms of neuropathic pain. This might allow a better understanding of the pathogenesis of neuropathic pain, and facilitate the discovery of specific therapies and new treatment target.

Key words: neuropathic pain, proteomics, review