Abstract: Objective To study the effects of hyperbaric oxygen （HBO） therapy in patients with acute intracerebral hemorrhage on serum adhesion molecules. Methods 66 cases with acute intracerebral hemorrhage were divided into routine treatment group (n=33) and HBO treatment group (n=33). 30 health persons were selected as normal trontrol. The level of adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin, were measured before and after treatment. Results The levels of adhesion molecules in routine and HBO treatment groups were higher than those in normal control group when hospitalized (P<0.01). All the adhesion molecules levels in two treatment group were decreased after the treatment, and more significantly in HBO group (P<0.05). Conclusion HBO therapy may ameliorate the adhesion molecule abnormalities after intracerebral hemorrhage.

Key words: hyperbaric oxygen, intracerebral hemorrhage, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin