Abstract: Objective To explore the clinical characters of drug-associated spinal subarachnoiditis. Methods 6 patients with spinal subarachnoiditis were analyzed retrospectively. Results All the patients appeared acute onset, numbness and weakness of lower limbs, incontinence, dramatic increase of protein with normal or mild increase of WBC in cerebral fluid regulation. Conclusion Spinal subarachnoiditis, if occurs, is resistant to variety of medication, and lead to the poor outcome. Prevention is most important.

Key words: drug-associated, spinal subarachnoiditis, clinical features, prevention