Abstract: Objective To study the effect of exercise training on the expression of Caspase-3 and IL-1β in rats with focal cerebral ischemia-reperfusion.Methods Seventy rats were recruited in this study and randomly divided into 4 groups: sham operation group, ischemic reperfusion group, ischemic reperfusion group with 10 min exercise per day, and ischemic reperfusion group with 30 min exercise per day. The exercise training was swimming training daily after the operation. Results Six months after training the Caspase-3 and IL-1β in ischemic cerebral tissue with 30 min was lower than that in ischemic reperfusion group(P<0.05). Conclusion Exercise training may improve the functional recovery of extremities in rats with cerebral ischemia-reperfusion, and the mechanism was related to decrease the expression of poisonous factors.

Key words: cerebral ischemia, rat, exercise training, Caspase-3, IL-1β