Abstract: ObjectiveTo explore the atorvastatin impact of pretreatment on spinal cord ischemia-reperfusion injured model of rabbits.MethodsThe animal model was induced by occlusion abdominal aorta. Spinal cord was performed for 45 min ischemia and neuronal function was evaluated at 2 h, 6 h, 12 h, and 24 h after reperfusion. The contents of malonydialdehyde (MDA), superoxide dismutase (SOD) and myeloperoxidase (MPO) were assayed 24 h after reperfusion.ResultsThe neuronal function decreased significantly 12 h and 24 h after reperfusion. The activity of SOD significantly enhanced, MDA contents and the activity of MPO decreased at medium-dose and high-dose atorvastatin.ConclusionAtorvastatin has protective effect on the spinal cord ischemia-reperfusion injury of rabbits.

Key words: atorvastatin, spinal cord, ischemia-reperfusion