CJRTP

《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2010, Vol. 16 ›› Issue (11): 1024-1026.

• 论文 • Previous Articles     Next Articles

Safety of Sarcoplasmic Reticulum Ca2+-ATPase Gene Transfer by Intramyocardium Administration in Chronic Heart Failure Beagles

FU Zhi-qing, LI Xiao-ying, LU Xiao-chun, et al   

  1. Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China
  • Received:2010-06-11 Revised:1900-01-01 Published:2010-11-25 Online:2010-11-25

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Abstract: ObjectiveTo assess the safety of intramyocardium injection of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) to rescue chronic heart failure beagles. MethodsThe heart failure beagles were assessed with myocardium enzymology, cAMP content of myocardium, myocardial oxygen consumption, arrhythmia, systemic inflammation factors, and the function of liver and kidney after SERCA2a gene transferred. ResultsThere were no increase of cAMP content, no more arrhythmia, myocardial oxygen consumption, no apparente systemic inflammation, and no injures to hepatic and renal function. ConclusionOverexpression of SERCA2a by intramyocardium injection is relatively safe.

Key words: chronic heart failure, sarcoplasmic reticulum Ca2+-ATPase, gene therapy, intramyocardium injection, safety, beagles