Abstract: ObjectiveTo evaluate the effect of double dosage tolterodine (4 mg/d) on patients with detrusor overactivity after spinal cord injury (SCI).Methods30 patients with detrusor overactivity after SCI who poorly responsed to tolterodine (2 mg/d) were treated with double dosage tolterodine. Urine leakage and quality of life by ICI-Q-SF was used to assess the treatment effect.Results28 of 30 patients completed this study after 4 weeks. 2 patients quited for dry mouth. After treatment with double dosage tolterodine, bladder capacity increased significantly from (196.3±44.7) ml to (393.5±54.3) ml, urine leakage decreased from (4.96±2.15) to (3.92±2.14) times per day. 25 of the 28 patients showed improvement in quality of life by ICI-Q-SF. ConclusionTreatment with double dosage tolterodine showed improvements in bladder capacity and urine leakage in patients with detrusor overactivity after SCI if the patients could tolerate the dry mouth and other side effects.

Key words: tolterodine, spinal cord injury, detrusor overactivity