大鼠全脑缺血-再灌注损伤后APC-Cdh1蛋白的表达

Abstract

Abstract: ObjectiveTo investigate the expression of APC-Cdh1 protein after cerebral ischemia-reperfusion injury.Methods60 male Sprague-Dawley rats were randomly divided into Sham-operated group(SH) and ischemia-reperfusion group(IR). The rats of ischemia-reperfusion groups were induced by four-vessel occlusion (4-VO). At different times after injury, the expression of APC-Cdh1 of rat hippocampus was observed by Western blotting and immunohistochemistry.ResultsCompared with sham-operated group, the expression of Cdh1 protein significantly decreased 1 day and increased obviously 3 days, but decreased again 7 days after injury in ischemia-reperfusion group. The immuno-staining showed that APC-Cdh1 was highly cerebral cortex and hippocampus in ischemia-reperfusion group. ConclusionAPC-Cdh1 may be involved in the central nervous system injury.

Key words: brain ischemia, hippocampus, anaphase promoting complex

CHEN Zhi-ze;WAN Li;QI Yue-hong;et al.. Expression of APC-Cdh1 Protein after Cerebral Ischemia-reperfusion Damage in Rats[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2010, 16(4): 339-341.

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Expression of APC-Cdh1 Protein after Cerebral Ischemia-reperfusion Damage in Rats

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