《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2010, Vol. 16 ›› Issue (5): 413-414.
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LIU Chang-fu, HUO Xiao-kun, YANG Ting-shu, et al.
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Abstract: ObjectiveTo study the effects of anti-aldosterone on left ventricular function in patients with myocardial infarction. Methods130 patients with myocardial infarction were divided into anti-aldosterone group (spironolactone 20~40 mg/d + enalapril 10~20 mg/day, n=61) and control group (enalapril 10~20 mg/d, n=69). The echocardiogram and Doppler tissue imaging (DTI) were performed at enrolling time, and 6, 12 months after treatment. ResultsIn the anti-aldosterone group, the average mitral systolic wave (s) was significantly increased 6 months after treatment (P<0.05) to the enrolling time. LVEF and LVEDD improved 12 months after treatment (P<0.05). In the control group, the average mitral systolic wave, LVEDD and LVEF did not significantly improve (P>0.05). Ratio of peak early to late diastolic filling velocity (e/a) was no significantly different between the anti-aldosterone group and the control group. ConclusionThe combination of anti-aldosterone and ACEI in patients with myocardial infarction can improve the left ventricular systolic function after 6 and 12 months, but cannot to the diastolic function.
Key words: myocardial infarction, aldosterone antagonists, Doppler tissue imaging, cardiac function
LIU Chang-fu;HUO Xiao-kun;YANG Ting-shu;et al.. Cardiac Function in Patients with Myocardial Infarction Treated with Spironolactone: A Doppler Tissue Imaging Study[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2010, 16(5): 413-414.
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