抗癫痫药对癫痫患者认知功能的影响

《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2010, Vol. 16 ›› Issue (7): 648-649.

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Impact of Antiepileptic Drugs on Cognitive Function of Epilepsy Patients

SUN Wei, MAO Wei, WANG Yu-ping, et al.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beiing 100053, China

Received:2010-05-10 Revised:1900-01-01 Published:2010-07-25 Online:2010-07-25

Abstract

Abstract: ObjectiveTo evaluate the cognitive impairment in epilepsy patients with Topiramate (TPM) or Valproate (VPA) treatment by using WAIS-CR. Methods30 untreated epilepsy patients were divided into two groups receiving TPM or VPA, respectively. All the patients were examined with WAIS-CR before and 3 months after treatment. ResultsThe IQ of TPM group decreased 3 months after treatment (P<0.05). ConclusionTPM may impair the cognitive function in epileptics reflected by decreased IQ.

Key words: epilepsy, Topiramate, Valproate, cognition, Wechsler Adult Intelligence Scale

SUN Wei;MAO Wei;WANG Yu-ping;et al.. Impact of Antiepileptic Drugs on Cognitive Function of Epilepsy Patients[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2010, 16(7): 648-649.

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Impact of Antiepileptic Drugs on Cognitive Function of Epilepsy Patients

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