Abstract: ObjectiveTo explore the diagnosis and treatment in multiple sclerosis with pain symptom.MethodsThe clinical data of 362 patients suffered from multiple sclerosis with pain symptom from January 1999 to December 2009 were analyzed retrospectively.ResultsPain symptom could result from different causes. Acute radicular pain and Lhermitte's sign were common in the acute pain syndromes as dysaesthetic extremity pain and painful spasticity in chronic pain syndromes. Individual therapy of selected cases showed a benefit of decreased pain symptom.ConclusionPain is a common clinical symptom of multiple sclerosis. Individualized therapeutic decisions could relieve symptom and improve outcome.

Key words: multiple sclerosis, pain symptom, treatment