《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2011, Vol. 17 ›› Issue (1): 56-58.
• 论文 • Previous Articles Next Articles
LIN Zhi-jun, CHEN Yu-sen, XIAN Wen-chuan, et al.
Received:
Revised:
Published:
Online:
Abstract: ObjectiveTo investigate the relationship between Parkinson disease (PD) and intron rs12138592 A/G polymorphism of ubiquitin specific proteases (USP24) gene in Han population of the Western Guangdong province in China. Methods81 PD cases and 100 ethnically matched controls were investigated USP24 gene rs12138592 A/G polymorphism with polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). ResultsThe incidence of GG genotype was 77.8% in the cases and 62.0% in the controls (χ2=5.213,P=0.022), and the G allele was 88.3% in the cases, 79.5% in the controls (χ2=4.980,P=0.026). ConclusionThe G allele and GG genotype of USP24 gene rs12138592 A/G polymorphism can increase the risk of suffering from PD.
Key words: ubiquitin specific proteases 24 gene, single-nucleotide polymorphism, Parkinson disease
LIN Zhi-jun;CHEN Yu-sen;XIAN Wen-chuan;et al.. Association of Intron rs12138592 A/G polymorphism of Ubiquitin Specific Proteases (USP24) Gene with Parkinson Disease[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2011, 17(1): 56-58.
0 / / Recommend
Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks
URL: https://www.cjrtponline.com/EN/
https://www.cjrtponline.com/EN/Y2011/V17/I1/56