《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2012, Vol. 18 ›› Issue (3): 215-218.
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XU Qian, SUN Zhen-rong, LI Gui-lin, et al.
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Abstract: Objective To investigate the distribution of aquaporin 4 (AQP4) and inwardly rectifying potassium channel 4.1 (Kir4.1) inthe astrocytes from human mesial temporal lobe epilepsy (MTLE). Methods Hippocampal specimens, including 10 cases of MTLE and 6cases of non-MTLE, were observed under optical and transmission electron microscopy. The distribution of AQP4 and Kir4.1 in astrocyteswas investigated with immunoflurescence. Results Compared with non-MTLE hippocampus, the main structural changes of MTLE includedremarkable hyperplasia astrocytes, serious swelling astrocytes and distinguished astrophy neurons. In non-MTLE hippocampus, immunoflurescencesignals of AQP4 and Kir4.1 were enriched along perivascular astrocyte end-feet domain. However, it reveals significant loss ofAQP4 and Kir4.1 in perivascular astrocyte end-feet domain in MTLE. Conclusion Loss of perivascular AQP4 and Kir4.1 in the humanMTLE may help to understand the roles of astrocyte in MTLE.
Key words: mesial temporal lobe epilepsy, aquaporin 4, inwardly rectifying potassium channel 4.1
XU Qian;SUN Zhen-rong;LI Gui-lin;et al.. Loss of Perivascular Aquaporin 4 and Inwardly Rectifying Potassium Channel 4.1 in Human Mesial Temporal Lobe Epilepsy[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2012, 18(3): 215-218.
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