Abstract: Objective To investigate the effect of high-voltage electrostatic therapy on chronic migraine. Methods 86 cases who met inclusioncriteria were randomly divided into two groups: high-voltage group (n=43) was treated with high-voltage therapeutic device for 20d. Control group (n=43) was blank control. The recovered cases were followed up for 4 weeks after cessation of treatment. They were assessedwith McGill Pain Questionnaire (MPQ), and their results of laboratory tests were recorded before and after treatment. The data set analyzedincluded Intention-To-Treat, and per protocol. Results The differences between 2 groups were statistically significant in Pain RatingIndex, Visual Analog Score and Present Pain Intensity after treatment (P<0.05). 6 patients in the treatment group and 1 patient in the controlgroup recovered. During the 4-week follow-up, 1 case recured in each group, the intensity of pain was not statistically significant. There wasno difference in the laboratory indice of blood, urine, stool routine, liver and kidney function (ALT, BUN, Cr) and ECG in both groups beforeand after treatment. Conclusion The high-voltage electrostatic therapy is effective and safe on chronic migraine.

Key words: migraine, high-voltage electrostatic therapy, McGill Pain Questionnaire