Abstract: Objective To explore the effect of Bushen decoction on Na⁺-K⁺ATPase 、Ca²⁺-Mg²⁺ATPase and succinate dehydrogenase(SDH) in rats with heart failure. Methods 60 heart failure rats were established by ligating left anterial descending coronary artery. Theywere randomly divided into model group, sham operation group, trimetazidine group, Bushen low-dose group, Bushen middle-dose groupand Bushen high-dose group with 10 rats in each group. They were gavaged 2 weeks after modeling for 8 weeks, hemodynamic changes includingleft ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVEDP), and the maximum rate left ventricular pressurerised or decreased (±LVdp/dt_max) were recorded as well as the level of Na⁺-K⁺ATP ase、Ca²⁺-Mg²⁺ATPase and SDH through the spectrophotometer.Results Compared with the sham operation group, the LVSP and + LVdp/dt_max of rats in model group decreased (P<0.05), LVEDPand -LVdp/dt_max increased (P<0.05). After Bushen intervention, contractility and diastolic function of myocardial of rats in middle and highdose group were better than model group (P<0.01), especially in high dose group.
Na⁺-K⁺ATP ase、Ca²⁺-Mg²⁺ATPase and SDH activity werehigher in Bushen groups than the model group, but lower than the sham operation group. With the increase of the doses, Na⁺-K⁺ATP ase、Ca²⁺-Mg²⁺ATPase and SDH activity gradually increased. Conclusion Bushen decoction can improve the cardiac function of rats with heartfailure that may be associated with Na+-K+ATPase, Ca2+-Mg2+ATPase and SDH activity.

Key words: Bushen decoction, hemodynamics, Na⁺-K⁺ATPase, Ca²⁺-Mg²⁺ATPase, succinate dehydrogenase, heart failure, rats