Abstract: Objective To study the effect of Botulinum toxin type A (BTX-A) on lower limbs spasticity after stroke. Methods 109 convalescent patients after stroke were randomly divided into treatment group and the control group. All the patients accepted routine treatment and rehabilitation, the treatment group accepted BTX-A injected in spastic muscles in addition. They were assessed with Fugl-Meyer assessment (FMA), modified Ashworth scale (MAS), Berg Balance Scale (BBS) before, 4 weeks and 12 weeks after treatment. Results The scores of MAS, BBS and FMA improved more in the treatment group than in the control group (P<0.05) after treatment. Conclusion Combination of local BTX-A injection can significantly release the lower limbs spasticity, and improve the motor and balance ability for patients after stroke.

Key words: stroke, lower limb spasticity, rehabilitation, Botulinum toxin type A