《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2013, Vol. 19 ›› Issue (09): 820-823.

• 论文 • Previous Articles     Next Articles

Effects of Monocyte Chemoattractant Protein-1 on Migration of Endogenous Neural Stem Cells

DING Peng, ZHOU Chang-sheng,DAI Xiao-sen, et al.   

  1. Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan, China
  • Received:2013-01-30 Revised:2013-03-09 Published:2013-09-25 Online:2013-09-25

Abstract: Objective To investigate the effects of monocyte chemoattractant protein-1 (MCP-1) on the migration of neural stem cells in vivo. Methods The brain injured rat model was established with cortical micro-injection of lipopolysaccharide in Sprague-Dawley rats. The tissue of brain was immunohistochemistrically stained to detect the expression of MCP-1 and nestin 3 d, 5 d, and 7 d after modeling. Results The expression of MCP-1 increased, and reached a peak 5 d after modeling. The nestin-positive cells was found in the lipopolysaccharide injected area 7 d after modeling. Conclusion MCP-1 may induce the endogenous neural stem cells migrate to lipopolysaccharide injection area in vivo.

Key words: cerebral injury, neural stem cells, monocyte chemoattractant protein-1, migration, rats