《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2013, Vol. 19 ›› Issue (2): 129-131.
• 论文 • Previous Articles Next Articles
FU Zhi-qing, LI Xiao-ying, LU Xiao-chun, et al.
Received:
Revised:
Published:
Online:
Abstract: Objective To explore the effect of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) overexpression on neuroendocrine system in chronic heart failure beagles. Methods The cardiac contraction function of chronic heart failure beagles were assessed by echocardiography before and after SERCA2a gene transduction. Radiation immune method was used to test the serum level of neuroendocrine factors such as Angiotensin Ⅱ, atrial natriuretic peptide, endothelin-1 and TNF-α, IL-6. Results The cardiac contraction function of chronic heart failure beagles improved greatly (P<0.05), and the serum levels of neuroendocrine factors significantly reduced after SERCA2a overexpression (P<0.05). Conclusion The vicious circle of neuroendocrine system may be blocked partially by SERCA2a overexpression.
Key words: chronic heart failure, sarcoplasmic reticulum Ca2+-ATPase, overexpression, neuroendocrine system
FU Zhi-qing;LI Xiao-ying;LU Xiao-chun;et al.. Effect of Sarcoplasmic Reticulum Ca2 +-ATPase Overexpression on Neuroendocrine System in Chronic Heart Failure Beagles[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2013, 19(2): 129-131.
0 / / Recommend
Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks
URL: https://www.cjrtponline.com/EN/
https://www.cjrtponline.com/EN/Y2013/V19/I2/129