Abstract: Early physical therapy intervention is important in improving the long-term outcome of the infants with high-risk of cerebral palsy. The early intervention programs that included child and parents were reported to affect the motor development of the high-risk infants.The approaches of early physical therapy included Vojta approach, Bobath approach and Doman-Delecato approach, etc. The Vojta approach has been regarded as advantages in early intervention. However, there are fewer studies on the effect of special motor training programs on motor development in high-risk infants

Key words: cerebral palsy, high risk infants, central coordination disorder, physical therapy, early intervention, review