Abstract: The pathogenesis of migraine is not fully understood as yet. Recently, with the development of ultrasonography, some studies indicated that the prevalence of right-to-left shunt (RLS) seemed to be higher in migraine, especially in migraine with aura. The progress in the relationship between migraine and RLS was reviewed.

Key words: migraine, cardiac right-to-left shunts, patent foramen ovale closure, review