CJRTP

《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2015, Vol. 21 ›› Issue (04): 432-435.

• 基础研究 • Previous Articles     Next Articles

Expression of Tumor Necrosis Factor-α and Interleukin-6 in Invasive Pituitary Adenoma

WU Jian-long1a, QIAO Jian-yong1b, DUAN Qing-hua1a
   

  1. 1. a. Department of Pathology; b. Department of Neurosurgery, Chengde Central Hospital, Chengde, Hebei 067000, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-04-25 Online:2015-04-25

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Abstract: Objective To study the tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) expressed in invasive pituitary adenomas (IPA). Methods The expression of TNF-α and IL-6 were observed with immunohistochemstry (SP approach) in tissue from 40 cases of non-invasive pituitary adenomas (NIPA) and 40 cases of IPA. Results The expression of both TNF-α and IL-6 was significantly increased in the IPA tissues compared with those of NIPA (P<0.05). Conclusion TNF-α and IL-6 may play a role in the occurrence and development of IPA.

Key words: invasive pituitary adenoma, tumor necrosis factor-α, interleukin-6