Abstract: Endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) can adjust the recovery of blood flow after cerebral ischemia, inhibit inflammatory reaction and promote the regeneration of the nerve and blood vessels. The gene polymorphism of eNOS is closely related to the onset of ischemic cerebrovascular disease. This article reviewed the relationship between eNOS and ischemic cerebrovascular disease.

Key words: ischemic cerebrovascular disease, endothelial nitric oxide synthase, nitric oxide, gene polymorphism, endothelial progenitor cell, review