Abstract: Hypoxic-ischemic brain damage is a serious complication of perinatal asphyxia. Enriched environment is the living conditions for the promotion of feeling, cognition and behavior. Enriched environment may promote the repairing of hypoxic-ischemic brain damage in term of praxiology, morphology and molecular biology, that enriched environment may regulate the secretion and release of various factors, and enhance synaptic plasticity, induce neuron regeneration, inhibit its apoptosis, and result in ethological and morphological recovery.

Key words: hypoxic-ischemic brain damage, enriched environment, rehabilitation, mechanisms, review